Preheat oven to 375 degrees F. Butter a 3-quart casserole dish.
Toss Panko with 1/4 cup Parmesan and 2 tbsp melted butter and set aside.
Fill a large pasta pot with water, salt generously, and bring to a boil. Once boiling, add the macaroni and cook until al dente. You really want it underdone as it will continue to cook in the oven. Drain in a colander and rinse under cold water
Meanwhile, in a medium saucepan over medium heat, warm the milk.
Melt 6 tbsp butter in another medium saucepan over medium heat. When the butter bubbles, add the flour and whisk, cooking for 1 min. While whisking slowly, pour in the hot milk a bit at a time until it's all incorporated. Let the mixture thicken and bubble while whisking constantly.
Remove from heat and add the dry mustard, salt, nutmeg, black pepper, and cayenne pepper. Whisk well.
Add shredded cheddar cheese and 1/2 cup Parmesan, and whisk until the cheese is melted. Set cheese sauce aside if pasta is not ready yet. Stir the cheese sauce occasionally so a skin doesn't form on top.
Stir macaroni into the cheese sauce. Pour mixture into the prepared casserole dish. Sprinkle on the panko crumbs.
Bake for 30-45 minutes or until browned on the top and bubbling. Remove from oven and let cool for 5 minutes before serving.